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Date of birth: April 5, 1978
Nationality: Russian
Educational history:
1985-1995 - studing at the secondary school №83, Izhevsk, Republic of Udmurtia, Russia
1995-2000 - studing at the Udmurt State University (Izhevsk, Republic of Udmurtia, Russia), the sub-faculty of Biochemistry of the Medical Biotechnology Faculty. Specialization- Biochemistry.
1999-2000 - special training in Molecular Biology at the Pushchino Branch of the Moscow State University and research training at the Institute of Protein Research, Russian Academy of Sciences (Pushchino, Moscow Region, Russia).
April 2000 - December 2002 - special training in 3D-reconstruction and cryo-EM at Imperial College of Science, Technology and Medicine, Wolfson Laboratories, Department of Biochemistry, London SW2 2AY, UK
Languages:
Native Russian, advanced English
Major fields of training and research experience:
Study of structural properties of the 70S ribosome and its complexes with different ligands by cryo-EM. 3D-reconstruction and analysis of mutant forms of the ribosome.
Publication:
Klaholz, B. P., Pape, T., Zavialov, A. V., Myasnikov, A. G., Orlova, E. V., Vestergaard, B., Ehrenberg, M., and Van Heel, M. (2003) Structure of the Escherichia coli ribosomal termination complex with release factor 2. Nature, 421, 90-4
O. N. Avdeeva, A. G. Myasnikov, P. V. Sergiev, A. A. Bogdanov, R. Brimacombe, and O. A. Dontsova (2002) Construction of the 'minimal' SRP that interacts with the translating ribosome but not with specific membrane receptors in Escherichia coli. FEBS Lett., 514, 70-3.
B. P. Klaholz, T. Pape, A. G. Mysnikov, A. V. Zavialov, E. Orlova, M. Ehrenberg and M. van Heel Release factor-ribosome interactions revealed by combination of cryo-electron microscopy and crystallography Acta Cryst. (2002). A38 (Supplement), C7
Meeting presentations:
S.A. Shiryaev, A.G. Myasnikov (2000). The comparison of site-specific endonucleases BsuK29I and BamHI. The horizons of Physical and Chemical Biology. Pushchino, Moscow Region, May 28 - June 2.
O. N. Avdeeva, A. G. Myasnikov, P. V. Sergiev, A. A. Bogdanov, R. Brimacombe, and O. A. Dontsova (2001) Study of interaction between SRP and the Ribosome of E.Coli. Protein Synthesis, International Conference in honour of Alexander Spirin, August 27 - September 1, 2001
A. G. Myasnikov, B. P. Klaholz and M. van Heel (2002) Localisation of release factor 3 on the ribosome by cryo-electron microscopy. XIX IUCr Congress and General Assembly of the International Union of Crystallography, Geneva, Switzerland, August 6-15, 2002.
B. P. Klaholz, T. Pape, A. V. Zavialov, A. Myasnikov, L. Gross, R. Matadeen, M. Ehrenberg, M. van Heel. Localisation of release factor RF2 in an E. coli ribosomal termination complex by cryo electron microscopy. International Conference on Protein Synthesis in Honor of Alexander Spirin 2001, Institute of Protein Research, Pushchino, Moscow Region, Russia.
B. P. Klaholz, T. Pape, A. V. Zavialov, A. Myasnikov, L. Gross, R. Matadeen, M. Ehrenberg, M. van Heel. Localisation of release factor RF2 in an E. coli ribosomal termination complex by cryo electron microscopy at 10е resolution. ESRF user meeting 2002, workshop "Complementary methods in structural biology", Grenoble, France. Presented by Shaoxia Chen (M. van Heel group).
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